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Proceedings Paper

Random signal model for cDNA microarrays
Author(s): Yoganand Balagurunathan; Edward R. Dougherty; Yidong Chen; Michael L. Bittner; Jeffrey M. Trent
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Paper Abstract

The images resulting from cDNA microarrays are highly random. There are many aspects to this randomness, including spot size, shape, intensity, uniformity, and circularity, as well as both foreground and background noise. This paper presents a random model for the generation of microarray images. The model is complicated and contains over 20 parameters. It can be used to test microarray imaging algorithms and to simulate the effects of various dependencies within the image formation process.

Paper Details

Date Published: 4 June 2001
PDF: 8 pages
Proc. SPIE 4266, Microarrays: Optical Technologies and Informatics, (4 June 2001); doi: 10.1117/12.427985
Show Author Affiliations
Yoganand Balagurunathan, Texas A&M Univ. (United States)
Edward R. Dougherty, Texas A&M Univ. (United States)
Yidong Chen, National Human Genome Research Institute/National Institutes of Health (United States)
Michael L. Bittner, National Human Genome Research Institute/National Institutes of Health (United States)
Jeffrey M. Trent, National Human Genome Research Institute/National Institutes of Health (United States)


Published in SPIE Proceedings Vol. 4266:
Microarrays: Optical Technologies and Informatics
Michael L. Bittner; Yidong Chen; Andreas N. Dorsel; Edward R. Dougherty, Editor(s)

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