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Proceedings Paper

Micromachined therapeutic delivery systems: from concept to clinic
Author(s): Tejal A. Desai
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Paper Abstract

Microfabrication techniques which permit the creation of therapeutic delivery systems that possess a combination of structural, mechanical, and perhaps electronic features may surmount challenges associated with conventional delivery of therapy. In this review, delivery concepts are presented which capitalize on the strengths of microfabrication. Possible applications include micromachined silicon membranes to create implantable biocapsules for the immunoisolation of pancreatic islet cells--as a possible treatment for diabetes--and sustained release of injectable drugs needed over long time periods. Asymmetrical, drug- loaded microfabricated particles with specific ligands linked to the surface are proposed for improving oral bioavailability of peptide (and perhaps protein) drugs.

Paper Details

Date Published: 21 May 2001
PDF: 10 pages
Proc. SPIE 4265, Biomedical Instrumentation Based on Micro- and Nanotechnology, (21 May 2001); doi: 10.1117/12.427971
Show Author Affiliations
Tejal A. Desai, Univ. of Illinois/Chicago (United States)


Published in SPIE Proceedings Vol. 4265:
Biomedical Instrumentation Based on Micro- and Nanotechnology
Raymond P. Mariella; Dan V. Nicolau, Editor(s)

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