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Proceedings Paper

Biosensing with optical microcavities
Author(s): Steve Blair; Yan Chen
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Paper Abstract

The artificial resonances of dielectric optical microcavities can be used to enhance the detection sensitivity of evanescent-wave optical fluorescence biosensors to the binding of a labeled analyte to a biospecific monolayer. Microcavity sensors offer the high sensitivity of a slab waveguide evanescent fluorescence sensor of much larger sensing surface area. Alternatively, when compared to a slab waveguide of the same area, microcavity based sensors offer much improved sensitivity. In either case, the required number of bound analytes is dramatically reduced. These scaling relations are highly conducive to achieving large sensing arrays with small sample volumes.

Paper Details

Date Published: 21 May 2001
PDF: 9 pages
Proc. SPIE 4265, Biomedical Instrumentation Based on Micro- and Nanotechnology, (21 May 2001); doi: 10.1117/12.427963
Show Author Affiliations
Steve Blair, Univ. of Utah (United States)
Yan Chen, Univ. of Utah (United States)


Published in SPIE Proceedings Vol. 4265:
Biomedical Instrumentation Based on Micro- and Nanotechnology
Raymond P. Mariella; Dan V. Nicolau, Editor(s)

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