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Proceedings Paper

Measuring liquid volumes in subnanoliter wells
Author(s): Ian T. Young; Kari H. Hjelt; L. Richard van den Doel; Michael J. Vellekoop; Lucas J. van Vliet
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Paper Abstract

We are developing a method for high-throughput screening using arrays of `nanowells' built into a silicon substrate. These wells can serve as bioreactors for studying a variety of biochemical reactions such as the enzymatic activity that occurs in yeast metabolism. For a variety of studies it is important to know the volume of liquid that has been deposited in a given well and/or to monitor the evaporation of the liquid. Using silicon as our substrate means that we can take advantage of the ability to build microelectronics into the wells in order to develop `smart' wells.

Paper Details

Date Published: 21 May 2001
PDF: 6 pages
Proc. SPIE 4265, Biomedical Instrumentation Based on Micro- and Nanotechnology, (21 May 2001); doi: 10.1117/12.427959
Show Author Affiliations
Ian T. Young, Delft Univ. of Technology (Netherlands)
Kari H. Hjelt, Delft Univ. of Technology (Netherlands)
L. Richard van den Doel, Delft Univ. of Technology (Netherlands)
Michael J. Vellekoop, Delft Univ. of Technology (Netherlands)
Lucas J. van Vliet, Delft Univ. of Technology (Netherlands)

Published in SPIE Proceedings Vol. 4265:
Biomedical Instrumentation Based on Micro- and Nanotechnology
Raymond P. Mariella; Dan V. Nicolau, Editor(s)

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