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Proceedings Paper

Detection of pathogens using on-chip electrochemical analysis of PCR amplified DNA molecules
Author(s): Dalibor Hodko; Lindsay Raymer; Stephanie M. Herbst; James W. Magnuson; David Gaskin
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Paper Abstract

The sensitivity and speed of methods for the detection of microorganisms and/or cells need to be constantly improved to provide timely and accurate analysis in large number of important applications. Such applications range from detection of pathogens in drinking water, biological warfare agents, biomedical diagnostics and food industry. The trends toward miniaturization of sensors using microfluidic and nanofluidic on-chip devices will push current detection limits to lower concentrations than what is offered by the present analytical equipment and/or detection kids. Microfluidic devices have been used to perform DNA analysis, polymerase chain reaction analysis, capillary electrophoresis and hybridization to oligonucleotide probes. This paper describes a new approach for the detection of pathogens on contaminated surfaces, which will integrated sampling, concentration and detection of targeted microorganisms.

Paper Details

Date Published: 21 May 2001
PDF: 10 pages
Proc. SPIE 4265, Biomedical Instrumentation Based on Micro- and Nanotechnology, (21 May 2001); doi: 10.1117/12.427958
Show Author Affiliations
Dalibor Hodko, Lynntech, Inc. (United States)
Lindsay Raymer, Lynntech, Inc. (United States)
Stephanie M. Herbst, Lynntech, Inc. (United States)
James W. Magnuson, Lynntech, Inc. (United States)
David Gaskin, Lynntech, Inc. (United States)

Published in SPIE Proceedings Vol. 4265:
Biomedical Instrumentation Based on Micro- and Nanotechnology
Raymond P. Mariella; Dan V. Nicolau, Editor(s)

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