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Proceedings Paper

Noninvasive in-vivo tissue-modulated Raman spectroscopy of human blood: microcirculation and viscosity effects
Author(s): Joseph Chaiken; William F. Finney; Paul E. Knudson; Karen P. Peterson; Charles M. Peterson; Xiaoke Yang; Ruth S. Weinstock
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Paper Abstract

We recently presented the first Raman spectra of in vivo human blood. A brief review of how to obtain such spectra and then normalize them to the appropriate blood volume is given showing how to produce spectra that can be used for noninvasive quantitative analysis of blood in vivo. A more careful comparison of tissue modulated spectra with static in vitro and invasive in vivo spectra suggests that there are small microcirculation differences between individuals resulting in some variability in their noninvasive quantitation. This variability is based on the mechanism for blood volume normalization and various means for obtaining necessary corrections are suggested. We present new clinical data from individuals and groups supporting this mechanism and suggesting how such measurements might also be used to quantify various microcirculation abnormalities.

Paper Details

Date Published: 4 June 2001
PDF: 13 pages
Proc. SPIE 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, (4 June 2001); doi: 10.1117/12.427952
Show Author Affiliations
Joseph Chaiken, Syracuse Univ., Laser Chemical Corp., and LighTouch Medical Inc. (United States)
William F. Finney, Syracuse Univ. (United States)
Paul E. Knudson, SUNY Upstate Medical Univ. and VA Medical Ctr. (United States)
Karen P. Peterson, LighTouch Medical Inc. (United States)
Charles M. Peterson, LighTouch Medical Inc. (United States)
Xiaoke Yang, LighTouch Medical Inc. (United States)
Ruth S. Weinstock, SUNY Upstate Medical Univ. and VA Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 4254:
Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III
Tuan Vo-Dinh; Warren S. Grundfest; David A. Benaron, Editor(s)

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