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Proceedings Paper

Near-infrared spectroscopy study of tourniquet-induced forearm ischemia in patients with coronary artery disease
Author(s): Mario E. Giardini; Giovanni Guido Guizzetti; Matteo Bavera; Paolo Lago; Mario Corti; Colomba Falcone; Federico Pastore
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Paper Abstract

Near-Infrared Spectroscopy (NIRS) can be employed to monitor local changes in haemodynamics and oxygenation of human tissues. A preliminary study has been performed in order to evaluate the NIRS transmittance response to induced forearm ischaemia in patients with coronary artery disease (CAD). The population consists in 40 patients with cardiovascular risk factors and angiographically documented CAD, compared to a group of 13 normal subjects. By inflating and subsequently deflating a cuff placed around the patient arm, an ischaemia has been induced and released, and the patients have been observed until recovery of the basal conditions. A custom NIRS spectrometer has been used to collect the backscattered light intensities from the patient forearm throughout the ischaemic and the recovery phase. The time dependence of the near-infrared transmittance on the control group is consistent with the available literature. On the contrary, the magnitude and dynamics of the NIRS signal on the CAD patients show deviations from the documented normal behavior, which can be tentatively attributed to abnormal vessel stiffness. These preliminary results, while validating the performance of the IRIS spectrometer, are strongly conducive towards the applicability of the NIRS technique to ischaemia analysis and to the endothelial dysfunction characterization in CAD patients with cardiovascular risk factors.

Paper Details

Date Published: 4 June 2001
PDF: 6 pages
Proc. SPIE 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, (4 June 2001); doi: 10.1117/12.427938
Show Author Affiliations
Mario E. Giardini, INFM (Italy)
Giovanni Guido Guizzetti, INFM and Univ. degli Studi di Pavia (Italy)
Matteo Bavera, INFM (Italy)
Paolo Lago, INFM and Policlinico San Matteo (Italy)
Mario Corti, INFM and Univ. degli Studi di Milano (Italy)
Colomba Falcone, Policlinico San Matteo and Univ. degli Studi di Pavia (Italy)
Federico Pastore, Policlinico San Matteo (Italy)

Published in SPIE Proceedings Vol. 4254:
Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III
Tuan Vo-Dinh; Warren S. Grundfest; David A. Benaron, Editor(s)

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