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Proceedings Paper

Detection of malignant tissues by using infrared microscopy and fiber optic spectroscopy
Author(s): Uwe Bindig; Martina Meinke; Ingo H. Gersonde; Sergei Kravchik; Samuel Citron; Abraham Katzir; Gerhard J. Mueller
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Paper Abstract

In this work we present our effort to develop an infrared method to differentiate between malignant and healthy tissue in vivo. This paper will present the technical design of the laboratory set up and the results obtained in experiments carried out on melanoma tumors in the skin of male mice. Silver halide fibers were used to carry our ATR measurements on tumor sections. Further results were compared with detailed measurements carried out using an FTIR-microscope and thin tissue sections in the spectral range of 4000 - 900 cm-1. The results indicate that IR spectroscopy would be a useful tool for biodiagnosis, in vivo and in real time. The fiberoptic method described here will easily lend itself to endoscopic applications.

Paper Details

Date Published: 4 June 2001
PDF: 10 pages
Proc. SPIE 4253, Optical Fibers and Sensors for Medical Applications, (4 June 2001); doi: 10.1117/12.427922
Show Author Affiliations
Uwe Bindig, Laser- und Medizin-Technologie GmbH (Germany)
Martina Meinke, Humboldt-Univ. Berlin/Univ.-Hospital Charite (Germany)
Ingo H. Gersonde, Laser- und Medizin-Technologie GmbH (Germany)
Sergei Kravchik, Barzilay Hospital (Israel)
Samuel Citron, Barzilay Hospital (Israel)
Abraham Katzir, Tel-Aviv Univ. (Israel)
Gerhard J. Mueller, Laser- und Medizin-Technologie GmbH & Freie Univ. Berlin/Univ.-Hospital Benjamin Franklin (Germany)

Published in SPIE Proceedings Vol. 4253:
Optical Fibers and Sensors for Medical Applications
Israel Gannot, Editor(s)

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