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Proceedings Paper

High-resolution imaging of colonic mucosa using optical coherence tomography
Author(s): Ruikang K. Wang; James B. Elder; Victoria Smith
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Paper Abstract

We report further the capability of OCT to delineate the microstructures beneath the colonic tissue surface, and to discriminate the normal tissues form the diseased ones. The OCT system operating at central wavelength at 820 nm was used which has measured axial resolution of 12 microns in free space and transversal resolution at 16 microns. The tissue specimens were obtained form the patient in the theater, who diagnosed as bearing colonic cancer and underwent conventional operations in the Hospital, and imaged with the OCT within 0.5-1 hour of removal. More than 10 patients were studied. The result of this study indicates that the important clinical layers and features with depth down to 1~2.0 mm of the colonic mucosa could be clearly delineated with the OCT imaging, and their thickness correlates well with the histology. The OCT images are also able to differentiate the normal colonic mucosa from the diseased ones. In conclusion, OCT is capable of high- resolution in situ imaging of colonic microstructures, without the need for excisional biopsy.

Paper Details

Date Published: 23 May 2001
PDF: 5 pages
Proc. SPIE 4251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V, (23 May 2001); doi: 10.1117/12.427902
Show Author Affiliations
Ruikang K. Wang, Keele Univ. Postgraduate School of Medicine (United Kingdom)
James B. Elder, North Staffordshire Hospital Trust (United Kingdom)
Victoria Smith, North Staffordshire Hospital Trust (United Kingdom)

Published in SPIE Proceedings Vol. 4251:
Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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