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Proceedings Paper

Monitoring of lymph flow in microvessels by biomicroscopy and speckle-interferometry
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Paper Abstract

In the paper lymph flow in microvessels by two methods in norm and under influence of vasoactive drugs: N-nitro-L- Arginine (L-NNA, 10-4M and dimethyl sufoxide (DMSO, 30%) was studied. We measured absolute linear flow velocity by microscopic method and parameter proportional to velocity (M1) using the speckle-interferometry. Also other parameters of lymph and blood microcirculation were measured. The lymph flow differs from blood flow. The average flow velocity for the lymphatics is more than for the blood microvessels. The negative correlation between blood flow velocity and diameter of vessel absents in lymphatics. The phase contractions contribute to the lymph flow. The M1 in contracting lymphatics are of the same values in different vessels. But the non-contracting microvessels has very varying indexes of M1. Probably the wall movements during phasic contractions led to the change of speckle signals. The action of vasoactive drugs (L-NNA and DMSO) stimulates the lymph flow and phasic activity in microvessels of rat mesentery. The effects of L-NNA and DMSO on diameters are different. The constriction of microvessels prevailed at the DMSO application. The dilatation dominated at the L-NNA action.

Paper Details

Date Published: 23 May 2001
PDF: 5 pages
Proc. SPIE 4251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V, (23 May 2001); doi: 10.1117/12.427896
Show Author Affiliations
Ekateryna I. Galanzha, Saratov State Medical Univ. and Saratov State Univ. (Russia)
Anastasiya V. Solov'eva, Saratov State Medical Univ. (Russia)
Gregory E. Brill, Saratov State Medical Univ. (Russia)
Sergey S. Ulyanov, Saratov State Univ. (Russia)
Valery V. Tuchin, Saratov State Univ. (Russia)


Published in SPIE Proceedings Vol. 4251:
Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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