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Proceedings Paper

In-vivo evaluation of locally mapped refractive indices with OCT
Author(s): Alexander R. Knuettel; Slavtcho Bonev; Christian Kugler
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Paper Abstract

Besides morphological images created by optical coherence tomography (OCT), another inherent physical parameter is evaluated in skin tissue under in vivo conditions. Refractive indices may support tissue characterization for research and diagnostic purposes in cosmetics/pharmacy and medicine, respectively. To accomplish refractive index evaluation, the sample arm of our OCT setup has been arranged to minimize mechanical adjustment and yet accommodate a wide parameter range at the entire penetration depth of up to 1 mm. A simple algorithm for local mapping has been derived. Refractive index maps have been measured locally in skin of stratum corneum, epidermis and upper parts of the dermis. Dry and moist skin areas have been observed by refractive index evaluation.

Paper Details

Date Published: 23 May 2001
PDF: 8 pages
Proc. SPIE 4251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V, (23 May 2001); doi: 10.1117/12.427884
Show Author Affiliations
Alexander R. Knuettel, ISIS Optronics GmbH (Germany)
Slavtcho Bonev, ISIS Optronics GmbH (Germany)
Christian Kugler, ISIS Optronics GmbH (Germany)

Published in SPIE Proceedings Vol. 4251:
Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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