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Proceedings Paper

Minimally invasive ultrasound thermal therapy with MR thermal monitoring and guidance
Author(s): Chris J. Diederich; R. Jason Stafford; Roger E. Price; William H. Nau; Per Daniel Tyreus; Belinda Rivera; Donald Schomer; Lars Olsson; John D. Hazle
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Paper Abstract

In this study both transurethral and interstitial ultrasound thermal therapy were applied to thermally coagulate targeted portions of the canine prostate or brain and implanted TVT tumors while using MRI-based thermal mapping techniques to monitor the therapy. MRI was also used for target definition, positioning of the applicator, and evaluation of target viability post-therapy. The complex phase-difference mapping technique using an iGE-EPI sequence with lipid suppression was used for determining temperature elevations within the in vivo prostate or brain and surrounding structures. Calculated temperature distributions, thermal dose exposures, T2-wieghted & T1-contrast enhanced images, gross inspection, and histology of sectioned prostates and brains were in good agreement with each other in defining destroyed tissue zones. Interstitial and transurethral ultrasound applicators produce directed zones of thermal coagulation within targeted tissue and implanted tumor, which can be accurately monitored and evaluated by MRI.

Paper Details

Date Published: 1 June 2001
PDF: 5 pages
Proc. SPIE 4247, Thermal Treatment of Tissue: Energy Delivery and Assessment, (1 June 2001); doi: 10.1117/12.427856
Show Author Affiliations
Chris J. Diederich, Univ. of California/San Francisco (United States)
R. Jason Stafford, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Roger E. Price, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
William H. Nau, Univ. of California/San Francisco (United States)
Per Daniel Tyreus, Univ. of California/San Francisco (United States)
Belinda Rivera, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Donald Schomer, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Lars Olsson, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
John D. Hazle, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)


Published in SPIE Proceedings Vol. 4247:
Thermal Treatment of Tissue: Energy Delivery and Assessment
Thomas P. Ryan, Editor(s)

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