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Proceedings Paper

ICDC interstitial ultrasound applicators for high-temperature thermal therapy
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Paper Abstract

Theoretical and experimental approaches were used to evaluate Internally-Cooled Direct-Coupled (ICDC) ultrasound applicators for treating disease in the prostate and liver. 2-D and 3-D transient biothermal models, which account for dynamic tissue changes, were used to calculate temperature distributions and zones of coagulation. Experimental evaluations and verification of these models were performed using in vitro tissue and in vivo porcine and canine models. Devices of 2.2 mm outer diameter were evaluated under varied applied power schemes and cooling levels. Both duty cycle power application and PI-controlled power application were found to improve applicator performance by increasing radial depths of lesions with lower maximum temperature. ICDC applicators were found to be able to create 3-5 cm diameter lesions in liver and muscle under 15 minute treatment times using the optimal designs and power application schemes found in this study. From these initial feasibility studies it has been demonstrated that ICDC devices have potential for treating cancerous tumors in prostate, liver and possibly breast.

Paper Details

Date Published: 1 June 2001
PDF: 7 pages
Proc. SPIE 4247, Thermal Treatment of Tissue: Energy Delivery and Assessment, (1 June 2001); doi: 10.1117/12.427848
Show Author Affiliations
Per Daniel Tyreus, Univ. of California/San Francisco (United States)
Chris J. Diederich, Univ. of California/San Francisco (United States)
William H. Nau, Univ. of California/San Francisco (United States)

Published in SPIE Proceedings Vol. 4247:
Thermal Treatment of Tissue: Energy Delivery and Assessment
Thomas P. Ryan, Editor(s)

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