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Proceedings Paper

ED50 determination of corneal lesions produced by 1318-nm laser radiation pulses
Author(s): Bryan K. Ketzenberger; Thomas E. Johnson; Steven P. Wild; Kenneth B. Pletcher; William P. Roach
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Paper Abstract

High-energy use of 1318 nm laser systems is becoming more prevalent in military and industrial settings. Threshold, ED50, exposure data and mechanism of laser-tissue interaction need to be determined for this wavelength using appropriate animal models that allow for extrapolation to control human exposures. Threshold, ED50, exposure data at 1318 nm for retinal and corneal injury have previously been undertaken and reported for rhesus monkeys. Using comparable methods, we examine exposure data at 1318 nm to determine the ED50 and laser-tissue interaction in the rabbit model to evaluate cornea. We present preliminary data for the ED50 threshold on the cornea from exposure to 1318 nm single laser pulses. Delivery of laser energy is accomplished using an Nd:YAG system producing 1318 nm light in the 0.5 millisecond time exposure regime and in the range of 0 to 500 mJ. Results from this work will aid in the establishment of safety standards for near infrared laser systems.

Paper Details

Date Published: 21 May 2001
PDF: 8 pages
Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); doi: 10.1117/12.427844
Show Author Affiliations
Bryan K. Ketzenberger, Uniformed Services Univ. of the Health Sciences (United States)
Thomas E. Johnson, Uniformed Services Univ. of the Health Sciences (United States)
Steven P. Wild, Uniformed Services Univ. of the Health Sciences (United States)
Kenneth B. Pletcher, Uniformed Services Univ. of the Health Sciences (United States)
William P. Roach, Uniformed Services Univ. of the Health Sciences (United States)


Published in SPIE Proceedings Vol. 4244:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI
Lawrence S. Bass; Abraham Katzir; David S. Robinson; Hans-Dieter Reidenbach; Eugene A. Trowers; Timothy A. Woodward; Kenton W. Gregory; Lou Reinisch; C. Gaelyn Garrett; Kenneth Eugene Bartels; Lloyd P. Tate; George M. Peavy; Michael D. Lucroy; R. Rox Anderson; Kenneth Eugene Bartels; Lawrence S. Bass; C. Gaelyn Garrett; Kenton W. Gregory; Abraham Katzir; Nikiforos Kollias; Michael D. Lucroy; Reza S. Malek; J. Stuart Nelson; George M. Peavy; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers; Timothy A. Woodward; Reza S. Malek, Editor(s)

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