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Proceedings Paper

Photodynamic diagnostic in atherosclerotic artery wall of rabbits
Author(s): Elaine Aparecida Corbani; Katia Calligaris Rodrigues; Raduan Hage; Janaina Duarte; Landulfo Silveira; Antonio G. J. Balbin Villaverde; Renato Amaro Zangaro; Marcos T. T. Pacheco
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Paper Abstract

A growing number of studies have demonstrated that autofluorescence and induced fluorescence spectroscopy can be used to distinguish normal and abnormal tissues in vivo. Through photochemical accumulation in atherosclerotic lesions it is possible to obtain induced fluorescence, this accumulation has been demonstrated in many researches. The aim of this study was to diagnose, by aluminum phthalocyanine transadventitial fluorescence, atherosclerotic plaques in artery wall of rabbits. Five male Norfolk rabbits were submitted to a high level cholesterol diet for 9 weeks. When the blood cholesterol level reached around 1000 mg/dl three of these animals were injected intravenously 50(M/50(l of aluminum phthalocyanine (AlPc). After 24 hours these animals were submitted to a surgery to expose the iliac artery. The transadventitial fluorescence spectra were acquired in several points over the artery. Characteristic peaks of the collagen, the porphyrin and the induced by AlPc were observed.

Paper Details

Date Published: 21 May 2001
PDF: 8 pages
Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); doi: 10.1117/12.427832
Show Author Affiliations
Elaine Aparecida Corbani, Univ. do Vale do Paraiba (Brazil)
Katia Calligaris Rodrigues, Univ. do Vale do Paraiba (Brazil)
Raduan Hage, Univ. do Vale do Paraiba (Brazil)
Janaina Duarte, Univ. do Vale do Paraiba (Brazil)
Landulfo Silveira, Univ. do Vale do Paraiba (Brazil)
Antonio G. J. Balbin Villaverde, Univ. do Vale do Paraiba (Brazil)
Renato Amaro Zangaro, Univ. do Vale do Paraiba (Brazil)
Marcos T. T. Pacheco, Univ. do Vale do Paraiba (Brazil)

Published in SPIE Proceedings Vol. 4244:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI
Lawrence S. Bass; David S. Robinson; Eugene A. Trowers; Kenton W. Gregory; Lou Reinisch; Kenneth Eugene Bartels; R. Rox Anderson; Reza S. Malek; Kenneth Eugene Bartels; Lloyd P. Tate; Abraham Katzir; C. Gaelyn Garrett; Timothy A. Woodward; Hans-Dieter Reidenbach; George M. Peavy; Lawrence S. Bass; C. Gaelyn Garrett; Michael D. Lucroy; Kenton W. Gregory; Abraham Katzir; Nikiforos Kollias; Michael D. Lucroy; Reza S. Malek; J. Stuart Nelson; George M. Peavy; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers; Timothy A. Woodward, Editor(s)

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