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Proceedings Paper

Evolving role of mitomycin-C laryngology
Author(s): Steven V. Richards; C. Gaelyn Garrett M.D.
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Paper Abstract

Topical mitomycin-C, a chemotherapeutic agent and a fibroblast inhibitor, has been successfully used in larynx, primarily to treat stenosis. Subglottic, tracheal, and anterior glottic stenosis have all shown promising results in a canine model. Less favorable results have been obtained when topical mitomycin-C is used on the vocal folds following surgical excision of mucosa. In the vocal fold studies, laryngeal videostroboscopy revealed diminished mucosal wave vibration in the vocal folds treated with mitomycin-C as well as a more atrophic appearance to the vibratory surface. The tissue treated with mitomycin-C showed fewer fibroblasts and less collagen. However, inflammatory infiltrate was not significantly different between the treated and untreated tissue. These results are consistent with the known suppression of fibroblast proliferation by mitomycin-C. In contrast to the positive effects of mitomycin-C on stenosis, the observed decrease in the healing response in the vocal fold had negative consequences on vocal fold vibratory pattern.

Paper Details

Date Published: 21 May 2001
PDF: 4 pages
Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); doi: 10.1117/12.427826
Show Author Affiliations
Steven V. Richards, Vanderbilt Univ. Medical Ctr. (United States)
C. Gaelyn Garrett M.D., Vanderbilt Univ. Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 4244:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI
Lawrence S. Bass M.D.; David S. Robinson M.D.; Eugene A. Trowers M.D.; Kenton W. Gregory M.D.; Lou Reinisch; Kenneth Eugene Bartels D.V.M.; R. Rox Anderson M.D.; Reza S. Malek M.D.; Kenneth Eugene Bartels D.V.M.; Lloyd P. Tate V.D.M.; Abraham Katzir; C. Gaelyn Garrett M.D.; Timothy A. Woodward M.D.; Hans-Dieter Reidenbach; George M. Peavy D.V.M.; Lawrence S. Bass M.D.; C. Gaelyn Garrett M.D.; Michael D. Lucroy D.V.M.; Kenton W. Gregory M.D.; Abraham Katzir; Nikiforos Kollias; Michael D. Lucroy D.V.M.; Reza S. Malek M.D.; J. Stuart Nelson M.D.; George M. Peavy D.V.M.; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson M.D.; Lloyd P. Tate V.D.M.; Eugene A. Trowers M.D.; Timothy A. Woodward M.D., Editor(s)

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