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Proceedings Paper

Imaging the internal structure of the guinea pig cochlea using optical coherence tomography at 1310 nm
Author(s): Mark K. Yamaguchi; Johannes F. de Boer; Boris Hyle Park; Nader Nassif; Yonghua Zhao; Zhongping Chen; Brian Jet-Fei Wong
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Paper Abstract

Optical coherence tomography (OCT) was used to obtain cross sectional images of the internal structure of the cochlea in guinea pigs following sacrifice. The 1310 nm source (bandwidth (lambda) equals75 nm) allowed a penetration depth of approximately 1.5 mm. Cross-sectional images (1.87 x 2.00 mm, 10 x 10 micrometers /pixel) were acquired at a frame rate of 1 Hz. Access to the middle ear space was obtained by removing the mastoid bulla. Imaging was performed in situ and also in ex vivo temporal bones. The scala vestibuli, scala media, scala tympani, modiolus and all four and a half turns of the cochlea were identified. These images demonstrate the potential value of OCT for use in determining the internal structures of the cochlea with near-microscopic resolution and at near-real time frame rates.

Paper Details

Date Published: 21 May 2001
PDF: 7 pages
Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); doi: 10.1117/12.427820
Show Author Affiliations
Mark K. Yamaguchi, Beckman Laser Institute and Medical Clinic and Creighton Univ. School of Medicine (United States)
Johannes F. de Boer, Beckman Laser Institute and Medical Clinic and Massachusetts General Hospital (United States)
Boris Hyle Park, Beckman Laser Institute and Medical Clinic and Massachusetts General Hospital (United States)
Nader Nassif, Beckman Laser Institute and Medical Clinic (United States)
Yonghua Zhao, Beckman Laser Institute and Medical Clinic (United States)
Zhongping Chen, Beckman Laser Institute and Medical Clinic (United States)
Brian Jet-Fei Wong, Beckman Laser Institute and Medical Clinic (United States)


Published in SPIE Proceedings Vol. 4244:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI
Lawrence S. Bass; Abraham Katzir; David S. Robinson; Hans-Dieter Reidenbach; Eugene A. Trowers; Timothy A. Woodward; Kenton W. Gregory; Lou Reinisch; C. Gaelyn Garrett; Kenneth Eugene Bartels; Lloyd P. Tate; George M. Peavy; Michael D. Lucroy; R. Rox Anderson; Kenneth Eugene Bartels; Lawrence S. Bass; C. Gaelyn Garrett; Kenton W. Gregory; Abraham Katzir; Nikiforos Kollias; Michael D. Lucroy; Reza S. Malek; J. Stuart Nelson; George M. Peavy; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers; Timothy A. Woodward; Reza S. Malek, Editor(s)

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