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Proceedings Paper

Improved diagnosis and therapy of superficial transitional cell carcinoma (TCC) of the urinary bladder by 5-aminolevulinic-acid (5-ALA)-induced protoporphyrin IX (PPIX) fluorescence: a prospective
Author(s): Rainer M. Kuntz; Frank Ruecker
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Paper Abstract

The prognosis of superficial bladder cancer is strongly related to a high recurrence rate and the presence of concomitant plane tumor lesions such as severe dysplasia or carcinoma in situ. They are frequently overlooked on white light cystoscopy. Furthermore, the traditional transurethral tumor resection of superficial bladder tumor is frequently incomplete. This prospective study aimed to evaluate whether or not 5-ALA induced PPIX fluorescence cystoscopy could increase the detection of superficial bladder tumors and/or plane carcinoma in situ invisible on white light cystoscopy. 100 patients with superficial TCC of the urinary bladder underwent cystoscopy under white light and under blue fluorescence light. 2 hours (1-4 hours) prior to cystoscopy 50 ml 3 percent 5-ALA-solution were intravesically instilled into the empty bladder. All lesions visible on white light cystoscopy were compared with fluorescence findings and, vice versa, all fluorescence findings were compared with white light cystoscopy findings. All lesions visible under white light, and all lesions only visible under 5-ALA induced fluorescence were resected/biopsied and histologically examined.

Paper Details

Date Published: 21 May 2001
PDF: 6 pages
Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); doi: 10.1117/12.427811
Show Author Affiliations
Rainer M. Kuntz, Auguste-Viktoria-Hospital (Germany)
Frank Ruecker, Auguste-Viktoria-Hospital (Germany)


Published in SPIE Proceedings Vol. 4244:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI
Lawrence S. Bass; David S. Robinson; Eugene A. Trowers; Kenton W. Gregory; Lou Reinisch; Kenneth Eugene Bartels; R. Rox Anderson; Reza S. Malek; Kenneth Eugene Bartels; Lloyd P. Tate; Abraham Katzir; C. Gaelyn Garrett; Timothy A. Woodward; Hans-Dieter Reidenbach; George M. Peavy; Lawrence S. Bass; C. Gaelyn Garrett; Michael D. Lucroy; Kenton W. Gregory; Abraham Katzir; Nikiforos Kollias; Michael D. Lucroy; Reza S. Malek; J. Stuart Nelson; George M. Peavy; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers; Timothy A. Woodward, Editor(s)

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