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Proceedings Paper

In-vivo tissue repair using light-activated surgical adhesive in a porcine model
Author(s): Karen M. McNally-Heintzelman; Jill N. Riley; Tonya J. Dickson; Dong Ming Hou; Pamela Rogers; Keith L. March
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Paper Abstract

An in vivo study was conducted to investigate the feasibility, mechanical function, and chronic biocompatibility of a new light-activated surgical adhesive for achieving rapid hemostasis of the puncture site following diagnostic catheterization and interventional cardiac procedures. Porcine carotid arteries (nequals6) and femoral arteries (nequals6) were exposed, and an incision was made in the arterial walls using a 16G needle. The surgical adhesive, composed of a poly(L-lactic-co-glycolic acid) scaffold doped with the traditional protein solder mix of serum albumin and indocyanine green dye, was used to close the incisions in conjunction with an 805-nm diode laser. Blood flow was restored to the vessels immediately after the procedure and the incision sites were checked for patency. The strength and hemostatic abilities of the new surgical adhesive were evaluated in the context of arterial pressure, persistence of hemostatis and presence of any inflammatory reaction after 3 days. After this evaluation period, the surgical procedure was repeated on the carotid arteries (nequals6) and femoral arteries (nequals6) of three additional animals that had been heparinized prior to surgery to closer approximate the conditions seen in a typical vascular surgical setting.

Paper Details

Date Published: 21 May 2001
PDF: 7 pages
Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); doi: 10.1117/12.427796
Show Author Affiliations
Karen M. McNally-Heintzelman, Rose-Hulman Institute of Technology (United States)
Jill N. Riley, Rose-Hulman Institute of Technology (United States)
Tonya J. Dickson, Indiana Univ. School of Medicine (United States)
Dong Ming Hou, Indiana Univ. School of Medicine (United States)
Pamela Rogers, Indiana Univ. School of Medicine (United States)
Keith L. March, Indiana Univ. School of Medicine (United States)


Published in SPIE Proceedings Vol. 4244:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI
Lawrence S. Bass; David S. Robinson; Eugene A. Trowers; Kenton W. Gregory; Lou Reinisch; Kenneth Eugene Bartels; R. Rox Anderson; Reza S. Malek; Kenneth Eugene Bartels; Lloyd P. Tate; Abraham Katzir; C. Gaelyn Garrett; Timothy A. Woodward; Hans-Dieter Reidenbach; George M. Peavy; Lawrence S. Bass; C. Gaelyn Garrett; Michael D. Lucroy; Kenton W. Gregory; Abraham Katzir; Nikiforos Kollias; Michael D. Lucroy; Reza S. Malek; J. Stuart Nelson; George M. Peavy; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers; Timothy A. Woodward, Editor(s)

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