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Proceedings Paper

Tissue soldering with biodegradable polymer films: in-vitro investigation of hydration effects on weld strength
Author(s): Brian S. Sorg; Ashley J. Welch
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Paper Abstract

Previous work demonstrated increased breaking strengths of tissue repaired with liquid albumin solder reinforced with a biodegradable polymer film compared to unreinforced control specimens. It was hypothesized that the breaking strength increase was due to reinforcement of the liquid solder cohesive strength. Immersion in a moist environment can decrease the adhesion of solder to tissue and negate any strength benefits gained from reinforcement. The purpose of this study was to determine if hydrated specimens repaired with reinforced solder would still be stronger than unreinforced controls. A 50%(w/v) bovine serum albumin solder with 0.5 mg/mL Indocyanine Green dye was used to repair an incision in bovine aorta. The solder was coagulated with 806-nm diode laser light. A poly(DL-lactic- co-glycolic acid) film was used to reinforce the solder (the controls had no reinforcement). The repaired tissues were immersed in phosphate buffered saline for time periods of 1 and 2 days. The breaking strengths of all of the hydrated specimens decreased compared to the acute breaking strengths. However, the reinforced specimens still had larger breaking strengths than the unreinforced controls. These results indicate that reinforcement of a liquid albumin solder may have the potential to improve the breaking strength in a clinical setting.

Paper Details

Date Published: 21 May 2001
PDF: 9 pages
Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); doi: 10.1117/12.427788
Show Author Affiliations
Brian S. Sorg, Univ. of Texas at Austin (United States)
Ashley J. Welch, Univ. of Texas at Austin (United States)


Published in SPIE Proceedings Vol. 4244:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI
Lawrence S. Bass; Abraham Katzir; David S. Robinson; Hans-Dieter Reidenbach; Eugene A. Trowers; Timothy A. Woodward; Kenton W. Gregory; Lou Reinisch; C. Gaelyn Garrett; Kenneth Eugene Bartels; Lloyd P. Tate; George M. Peavy; Michael D. Lucroy; R. Rox Anderson; Kenneth Eugene Bartels; Lawrence S. Bass; C. Gaelyn Garrett; Kenton W. Gregory; Abraham Katzir; Nikiforos Kollias; Michael D. Lucroy; Reza S. Malek; J. Stuart Nelson; George M. Peavy; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers; Timothy A. Woodward; Reza S. Malek, Editor(s)

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