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Proceedings Paper

Cooperative phenomena in two-pulse two-color laser photocoagulation of cutaneous blood vessels
Author(s): John F. Black; Jennifer Kehlet Barton; George Frangineas; Herbert Pummer
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Paper Abstract

A novel laser system has been developed to study the effects of multiple laser pulses of differing wavelengths on cutaneous blood vessels in vivo, using the hamster dorsal skin flap preparation. The system permits sequenced irradiation with well-defined intrapulse spacing at 532 nm, using a long pulse frequency doubled Nd:YAG laser, and at 1064 nm, using a long pulse Nd:YAG laser. Using this system, we have identified a parameter space where two pulses of different wavelengths act in a synergistic manner to effect permanent vessel damage at radiant exposures where the two pulses individually have little or no effect. Using a two- color pump-probe technique in vitro, we have identified a phenomenon we call green-light-induced infrared absorption (GLIIRA), where a pulse of green light causes photochemical and photothermal modifications to the chemical constituents of blood and results in enhanced infrared absorption. We identify a new chemical species, met-hemoglobin, not normally present in healthy human blood but formed during laser photocoagulation which we believe is implicated in the enhanced IR absorption.

Paper Details

Date Published: 21 May 2001
PDF: 12 pages
Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); doi: 10.1117/12.427786
Show Author Affiliations
John F. Black, Coherent Medical Group (United States)
Jennifer Kehlet Barton, Univ. of Arizona (United States)
George Frangineas, Coherent Medical Group (United States)
Herbert Pummer, Coherent Medical Group (United States)


Published in SPIE Proceedings Vol. 4244:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI
Lawrence S. Bass; David S. Robinson; Eugene A. Trowers; Kenton W. Gregory; Lou Reinisch; Kenneth Eugene Bartels; R. Rox Anderson; Reza S. Malek; Kenneth Eugene Bartels; Lloyd P. Tate; Abraham Katzir; C. Gaelyn Garrett; Timothy A. Woodward; Hans-Dieter Reidenbach; George M. Peavy; Lawrence S. Bass; C. Gaelyn Garrett; Michael D. Lucroy; Kenton W. Gregory; Abraham Katzir; Nikiforos Kollias; Michael D. Lucroy; Reza S. Malek; J. Stuart Nelson; George M. Peavy; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers; Timothy A. Woodward, Editor(s)

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