Share Email Print
cover

Proceedings Paper

Spatially-resolved cerebral blood flow imaging using laser speckle
Author(s): Andrew K. Dunn; Hayrunnisa Bolay; Michael J. Moskowitz; David A. Boas
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Cerebral blood flow measurements are crucial for studying neuronal activity and cerebrovascular responses. Most optical techniques for monitoring real time blood flow rely on laser Doppler measurements which are limited to a localized region in space (point measurements). We have used the time-varying speckle pattern produced by coherent light scattered from moving particles to provide real-time, two-dimensional maps of capillary blood flow dynamics. The speckle images of relative blood flow during cortical spreading depression showed a 2-3 mm area of increased blood flow propagation with a velocity of 2.5 mm/min. The speckle technique therefore, provides a relatively simple method of obtaining spatially resolved cerebral blood flow changes in the exposed cortex with high temporal resolution (milliseconds).

Paper Details

Date Published: 10 May 2001
PDF: 4 pages
Proc. SPIE 4260, Optical Diagnostics of Living Cells IV, (10 May 2001); doi: 10.1117/12.426780
Show Author Affiliations
Andrew K. Dunn, Harvard Medical School/Massachusetts General Hospital (United States)
Hayrunnisa Bolay, Harvard Medical School/Massachusetts General Hospital (United States)
Michael J. Moskowitz, Harvard Medical School/Massachusetts General Hospital (United States)
David A. Boas, Harvard Medical School/Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 4260:
Optical Diagnostics of Living Cells IV
Daniel L. Farkas; Robert C. Leif; Robert C. Leif, Editor(s)

© SPIE. Terms of Use
Back to Top