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Proceedings Paper

Advanced development of the digital tuberculosis tester for MDR-TB screening
Author(s): Jason E. Smith; Michelle D. Simkulet; Alexander Gutin; Alexy Gutin; Savco Bardarov; William R. Jacobs Jr.; James Castracane; Oliver Tang; Paul Riska
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Paper Abstract

Tuberculosis (TB) remains the leading cause of death in the world from a single infectious disease, and the threat is becoming more critical with the spread of multi-drug resistant Tuberculosis (MDR-TB). TB detection, and susceptibility testing for drug resistant strain identification, is advancing with the development of Luciferase Reporter Mycobacteriophages (LRM). LRM will emit visible light at very low intensity when in the presence of live mycobacteria cells such as Tuberculosis strains. InterScience, Inc., together with its collaboration, is developing a highly sensitive, real-time digital detection system for the analysis of luminescent assays. Recent advances in system sensitivity, design, and implementation, as well as preliminary results of the development of individual test cartridges, will be presented. The ultimate goal of this work is to provide a versatile luminescence detection tool for widespread research and clinical applications.

Paper Details

Date Published: 22 May 2001
PDF: 7 pages
Proc. SPIE 4255, Clinical Diagnostic Systems, (22 May 2001); doi: 10.1117/12.426753
Show Author Affiliations
Jason E. Smith, InterScience, Inc. (United States)
Michelle D. Simkulet, InterScience, Inc. (United States)
Alexander Gutin, InterScience, Inc. (United States)
Alexy Gutin, InterScience, Inc. (United States)
Savco Bardarov, Albert Einstein College of Medicine/Yeshiva Univ. (United States)
William R. Jacobs Jr., Albert Einstein College of Medicine/Yeshiva Univ. (United States)
James Castracane, SUNY/Albany (United States)
Oliver Tang, SUNY/Albany (United States)
Paul Riska, SUNY/Brooklyn Health Science Ctr. (United States)

Published in SPIE Proceedings Vol. 4255:
Clinical Diagnostic Systems
Gerald E. Cohn, Editor(s)

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