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Proceedings Paper

Low-level laser therapy in chemo- and radiation-induced mucositis: results of multicenter phase III studies
Author(s): Rene-Jean Bensadoun
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Paper Abstract

Low of middle energy irradiation with helium-neon laser (LLLT) appears to be a simple atraumatic technique for the prevention and treatment of mucositis of various origins. Preliminary findings obtained by Ciais et al prompted randomized multi-center, double-blind trials to evaluate LLLT for the prevention of a acute chemo- and radiation- induced stomatitis. Irradiation by LLLT corresponds to local application of a high photon density monochromatic light source. Activation of epithelial healing on LLL-treated surfaces, the most commonly recognized effect, has been confirmed by numerous in vitro studies, and is a function of cell type, wavelength, and energy dose. The mechanism of action at a molecular and enzymatic level is currently being studied (detoxification of free-radicals).

Paper Details

Date Published: 26 April 2001
PDF: 6 pages
Proc. SPIE 4422, Low-Level Laser Therapy, (26 April 2001); doi: 10.1117/12.425525
Show Author Affiliations
Rene-Jean Bensadoun, Ctr. Antoine-Lacassagne (France)

Published in SPIE Proceedings Vol. 4422:
Low-Level Laser Therapy
Tatiana I. Solovieva, Editor(s)

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