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Proceedings Paper

Fluence rate effects in human glioma spheroids: implications for photodynamic therapy of brain tumors
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Paper Abstract

The effects of fluence rate are investigated in human glioma spheroids incubated in 5-aminolevulinic acid (ALA). It is shown that the response of glioma spheroids to ALA-mediated PDT depends strongly on the rate at which the light dose is delivered. At low doses, lower fluence rates are more effective. For example, at a dose of 50 JIcm2, near total spheroid kill is observed at fluence rates of as low as 1 0 mW/cm2. Below 1 0 mW/cm2, however, treatments are not as effective. The fluence rate effect is not as pronounced at higher doses where a favorable response is observed throughout the range of fluence rates investigated. The clinical implications ofthese findings are discussed.

Paper Details

Date Published: 9 April 2001
PDF: 7 pages
Proc. SPIE 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X, (9 April 2001); doi: 10.1117/12.424447
Show Author Affiliations
Steen J. Madsen, Univ. of Nevada/Las Vegas (United States)
Chung-Ho Sun, Beckman Laser Institute and Medical Ctr./Univ. of California/Irvine (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Ctr./Univ. of California/Irvine (United States)
Henry Hirschberg, Norwegian Radium Hospital (Norway)


Published in SPIE Proceedings Vol. 4248:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X
Thomas J. Dougherty, Editor(s)

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