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Proceedings Paper

Multispectral monitoring of fluorescence during ALA-PDT of superficial skin cancers
Author(s): Jacqueline Hewett; Valerie Nadeau; James Ferguson; Harry Moseley; Sally Ibbotson; Lorenzo Brancaleon; David J. Birkin; Wilson Sibbett; Miles J. Padgett
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Paper Abstract

We present a simple fluorescence imaging system for use in the demarcation and monitoring of skin cancers. The imaging system simultaneously acquires four spectrally specific images at 635, 600, 540 and 400nm. The incorporation of an image intensifier, coupled with high speed image processing gives video update rates. The integrated light source is based on low cost fluorescent bulbs, shaped to fit around the lens and phosphor coated to give a peak emission near 400nm, matched to the absorption maximum of PpIX. We apply this system to monitoring the fluorescence of the PpIX photosensitiser before during and after ALA based PDT.

Paper Details

Date Published: 9 April 2001
PDF: 8 pages
Proc. SPIE 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X, (9 April 2001); doi: 10.1117/12.424437
Show Author Affiliations
Jacqueline Hewett, Univ. of St. Andrews (United Kingdom)
Valerie Nadeau, Univ. of Glasgow (United Kingdom)
James Ferguson, Univ. of Dundee (United Kingdom)
Harry Moseley, Univ. of Dundee (United Kingdom)
Sally Ibbotson, Univ. of Dundee (United Kingdom)
Lorenzo Brancaleon, Univ. of Dundee (United Kingdom)
David J. Birkin, Univ. of St. Andrews (United Kingdom)
Wilson Sibbett, Univ. of St. Andrews (United Kingdom)
Miles J. Padgett, Univ. of Glasgow (United Kingdom)


Published in SPIE Proceedings Vol. 4248:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X
Thomas J. Dougherty, Editor(s)

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