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Proceedings Paper

Photodynamic therapy using Verteporfin and 630-nm laser light in canine esophagus
Author(s): Masoud Panjehpour; Robert C. DeNovo; Mark G. Petersen; Bergein F. Overholt; Barbara Kelly; Robert D. Bower; Valery Rubinchik
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Paper Abstract

Objective: The goal ofthis study was to determine a relationship between light dose and the delay time between administration of Verteporfin and light to ablate canine esophageal mucosa. Materials and Methods: Verteporfin was administered IV (0.75 mg/lg). 630-nm light from KTP/Dye laser was delivered using a 9-cm diffuser inside a specially designed reflective 7-cm windowed balloon. Initially, animals were treated at doses of 160 J/cm, 180 J/cm, 200 J/cm, and 220 J/cm 2-3 hours after Verteporfin injection. Based on the acute response in these animals and the plasma Verteporfin clearance, other treatments were devised and tested at 60 J/cm (at 1 5 minutes), 80 J/cm (22 minutes), 100 J/cm (30 minutes), and 145 J/cm (60 minutes). Results: In initial animals, 200 J/cm at 2 hours induced acceptable mucosal ablation. Using this light dose and the plasma drug clearance, subsequent treatments were tested resulting in similar injuries using 60 3/cm (15 minutes), 80 3/cm (22 minutes), 100 3/cm (30 minutes), and 145 J/cm (60 minutes). Conclusions: A relationship was established relating the light dose and the delay time between administration oflight and Verteporfin for ablation ofnormal canine esophageal mucosa.

Paper Details

Date Published: 9 April 2001
PDF: 7 pages
Proc. SPIE 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X, (9 April 2001); doi: 10.1117/12.424434
Show Author Affiliations
Masoud Panjehpour, Thompson Cancer Survival Ctr. (United States)
Robert C. DeNovo, Univ. of Tennessee/Knoxville (United States)
Mark G. Petersen, Univ. of Tennessee/Knoxville (United States)
Bergein F. Overholt, Thompson Cancer Survival Ctr. and Univ. of Tennessee/Knoxville (United States)
Barbara Kelly, QLT, Inc. (Canada)
Robert D. Bower, QLT, Inc. (Canada)
Valery Rubinchik, QLT, Inc. (Canada)


Published in SPIE Proceedings Vol. 4248:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X
Thomas J. Dougherty, Editor(s)

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