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Proceedings Paper

Photodynamic therapy for breast cancer with photosense
Author(s): Elena G. Vakoulovskaya M.D.; Victor V. Shental M.D.; Yury V. Buidenok; Georgui I. Solomakho; Tatiana M. Nadezhdina
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Paper Abstract

Photodynamic Therapy (PDT) using second-generation photosensitizer Aluminium Phtalocyanine (NIOPIC, Russia) (PS) in dose 0.5-0.8 mg per kg of body weight have been provided in 15 patients with breast cancer. In 5 patients with T2-T3NOMO primary tumor was treated as the preoperarive treatment, radical mastectomy has been fulfilled after PDT with subsequent histological examination. 10 patients had local recurrencies of breast cancer after combined treatment, chemotherapy and radiotherapy. Fluorescent diagnostics of tumor, accumulation of PS in tumor, adjacent tissue before and during PDT was fulfilled. For PDT semiconductive laser -X=672+2nm, P=1,5 W was used. Treating primary tumor interstitial irradiation has been done in light dose l5OJIcm3. In patients with skin metastases multiple surface irradiations were provided with interval 24-72 hours and total light dose 400-900 J/cm2. In cases of preoperative PDT pathomorphosis of different degree has been found in all cases. In patients with advanced skin recurrencies of breast cancer partial regression of tumor has been got in 2 monthes after PDT or progression with lung or bone metastasis. In 5patients with early skin metastases in 80% complete responce've been got 2 monthes after treatment with recurrencies in 6 monthes in 60% patients. Our experience show pronounced efficacy of PDT for treating breast cancer.

Paper Details

Date Published: 9 April 2001
PDF: 3 pages
Proc. SPIE 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X, (9 April 2001); doi: 10.1117/12.424433
Show Author Affiliations
Elena G. Vakoulovskaya M.D., Cancer Research Ctr. (Russia)
Victor V. Shental M.D., Cancer Research Ctr. (Russia)
Yury V. Buidenok, Cancer Research Ctr. (Russia)
Georgui I. Solomakho, Cancer Research Ctr. (Russia)
Tatiana M. Nadezhdina, Cancer Research Ctr. (Russia)

Published in SPIE Proceedings Vol. 4248:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X
Thomas J. Dougherty, Editor(s)

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