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Proceedings Paper

Endoscopic detection of early malignancies in the upper gastrointestinal tract using laser-induced fluorescence imaging
Author(s): Uwe Sukowski; Bernd Ebert; Marianne Ortner; Katharina Zumbusch; Karsten Mueller; Barbara Fleige; Herbert Lochs; Herbert H. Rinneberg
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Paper Abstract

Fluorescence images were recorded simultaneously with white light images to detect dyspasia or early malignancies during regular endoscopy of the upper gastrointestinal tract, after topical administration of 5-aminolaevulinic acid. Biopsies were taken at locations where fluorescence intensity were high compared with the mean fluorescence intensity of the image. Prompt and delayed fluorescence spectra of biopsies were subsequently recorded ex vivo, and normalized fluorescence intensities of Protoporphyrin IX derived from these spectra were compared with routine histology. In contrast to routine endoscopy, one early carcinoma and one signet-ring carcinoma were found in the stomach, and malignancies in a duodenal polyp. In addition, intestinal metaplasia could be visualized in the stomach of two patients, which had not been detected in biopsies taken prior to fluorescence endoscopy.

Paper Details

Date Published: 31 January 2001
PDF: 7 pages
Proc. SPIE 4156, Clinical Lasers and Diagnostics, (31 January 2001); doi: 10.1117/12.413710
Show Author Affiliations
Uwe Sukowski, Physikalisch-Technische Bundesanstalt (Germany)
Bernd Ebert, Physikalisch-Technische Bundesanstalt (Germany)
Marianne Ortner, Universitatsklinikum Charite der Humboldt-Univ. zu Berlin (Germany)
Katharina Zumbusch, Universitatsklinikum Charite der Humboldt-Univ. zu Berlin (Germany)
Karsten Mueller, Universitatsklinikum Charite der Humboldt-Univ. zu Berlin (Germany)
Barbara Fleige, Universitatsklinikum Charite der Humboldt-Univ. zu Berlin (Germany)
Herbert Lochs, Universitatsklinikum Charite der Humboldt-Univ. zu Berlin (Germany)
Herbert H. Rinneberg, Physikalisch-Technische Bundesanstalt (Germany)


Published in SPIE Proceedings Vol. 4156:
Clinical Lasers and Diagnostics
Patrick Brouwer, Editor(s)

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