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Proceedings Paper

Application of IR and NIR fiber optic imaging in thermographic and spectroscopic diagnosis of atherosclerotic vulnerable plaques: preliminary experience
Author(s): Morteza Naghavi; Tania Khan; Bujin Gu; Babs R. Soller; Peter Melling; Mohammed Asif; Khawar Gul; Mohammad Madjid; S. Ward Casscells; James T. Willerson
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Paper Abstract

Despite major advances in cardiovascular science and technology during the past three decades, approximately half of all myocardial infarctions and sudden deaths occur unexpectedly. It is widely accepted that coronary atherosclerotic plaques and thrombotic complications resulting from their rupture or erosion are the underlying causes of this major health problem. The majority of these vulnerable plaques exhibit active inflammation, a large necrotic lipid core, a thin fibrous cap, and confer a stenosis of less than 70%. These lesions are not detectable by stress testing or coronary angiography. Our group is exploring the possibility of a functional classification based on physiological variables such as plaque temperature, pH, oxygen consumption, lactate production etc. We have shown that heat accurately locates the inflamed plaques. We also demonstrated human atherosclerotic plaques are heterogeneous with regard to pH and hot plaques and are more likely to be acidic. To develop a nonsurgical method for locating the inflamed plaques, we are developing both IR fiber optic imaging and NIR spectroscopic systems in our laboratory to detect hot and acidic plaque in atherosclerotic arterial walls. Our findings introduce the possibility of an isolated/combined IR and NIR fiber optic catheter that can bring new insight into functional assessment of atherosclerotic plaque and thereby detection of active and inflamed lesions responsible for heart attacks and strokes.

Paper Details

Date Published: 15 December 2000
PDF: 14 pages
Proc. SPIE 4130, Infrared Technology and Applications XXVI, (15 December 2000); doi: 10.1117/12.409909
Show Author Affiliations
Morteza Naghavi, Texas Medical Ctr. and Medical School (United States)
Tania Khan, Univ. of Massachusetts Medical School (United States)
Bujin Gu, Univ. of Texas Medical School (United States)
Babs R. Soller, Univ. of Massachusetts Medical School (United States)
Peter Melling, RemSpec Inc. (United States)
Mohammed Asif, Univ. of Texas Medical School (United States)
Khawar Gul, Univ. of Texas Medical School (United States)
Mohammad Madjid, Univ. of Texas Medical School (United States)
S. Ward Casscells, Texas Medical Ctr. Medical School (United States)
James T. Willerson, Texas Medical Ctr. and Medical School (United States)


Published in SPIE Proceedings Vol. 4130:
Infrared Technology and Applications XXVI
Bjorn F. Andresen; Gabor F. Fulop; Marija Strojnik, Editor(s)

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