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Proceedings Paper

Comparison of competing fiber optic probes for tissue fluorescence analysis
Author(s): Nikolay A. Denisov
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Paper Abstract

Several fiber optic probes attached single- or multi-fiber light delivery systems have been competitively examined for purposes of in vivo tissue fluorescence spectroscopy with endoscopic technique use. The effects of the probes' designs and excitation/receiving fiber geometry on fluorescence spectra are analyzed with the sensor optical efficiency (SOE) coefficient and the tip coupling efficiency (TCE) one calculated by means of ray tracing. The profiles of the excitation beam as well as fluorescence profiles were simulated with uniform and Gaussian cross power distributions, whereas the diameter of the tissue surface area from which fluorescence light was collected was taken as five diameter of the tissue surface area directly illuminated by the excitation beam. The plots of the SOE-coefficients versus changeable probe-tissue gap simulated possible peristaltic tissue movement during clinical in situ spectroscopic optical biopsy would be a helpful tool for specialists to design novel endoscopic fiber optic catheters to differentiate normal and pathologic tissues.

Paper Details

Date Published: 16 November 2000
PDF: 10 pages
Proc. SPIE 4161, Optical Biopsy and Tissue Optics, (16 November 2000); doi: 10.1117/12.409334
Show Author Affiliations
Nikolay A. Denisov, National Technical Univ. of Ukraine (Ukraine)


Published in SPIE Proceedings Vol. 4161:
Optical Biopsy and Tissue Optics
Irving J. Bigio; Gerhard J. Mueller; Gerwin J. Puppels; Rudolf W. Steiner; Katarina Svanberg, Editor(s)

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