Share Email Print
cover

Proceedings Paper

Laser-induced thermotherapy (LITT): energy and temperature determination for complete in-situ ablation of liver metastasis
Author(s): Christoph Martin Isbert; Andre Roggan; Joerg-Peter Ritz; Gerhard J. Mueller; Heinz-Johannes Buhr; Kai-S. Lehmann; Christoph-Thomas Germer
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Purpose: The aim of this study was to determine the energy (J/mm3 tumor volume) and temperature required for a complete in-situ-ablation of experimental liver tumors. Methods: LITT was performed in VX-2 tumor-bearing rabbits using Nd-YAG-Laser (1064 nm) with a diffuser-tip applicator and a temperature feedback-system. The animals were randomized into 4 groups (n equals 20) that differed in the target temperature at the tumor border [45 degrees Celsius, 50 degrees Celsius, 55 degrees Celsius and 60 degrees Celsius]. Histological examination was done at 0 h, 24 h, 96 h and 14 days after LITT. Results: The pretreatment tumor volume of 2191 +/- 61 mm3 was the same for all groups (p > 0.05). Energy and temperature required and the rate of incomplete tumor-ablation (recurrences) are listed below (* equals p < 0.05, Kruskal-Wallis test. Conclusions: (1) To achieve complete in-situ-ablation under the given conditions, it is necessary to apply laser-energy of 3 J/mm3 tumor volume. (2) A minimum temperature of 60 degrees Celsius on the tumor border presumed an application of 10 minutes.

Paper Details

Date Published: 16 November 2000
PDF: 8 pages
Proc. SPIE 4161, Optical Biopsy and Tissue Optics, (16 November 2000); doi: 10.1117/12.409314
Show Author Affiliations
Christoph Martin Isbert, Universitaetsklinikum Benjamin Franklin der Freie Univ. Berlin (Germany)
Andre Roggan, Universitaetsklinikum Benjamin Franklin der Freie Univ. Berlin (Germany)
Joerg-Peter Ritz, Universitaetsklinikum Benjamin Franklin der Freie Univ. Berlin (Germany)
Gerhard J. Mueller, Universitaetsklinikum Benjamin Franklin der Freie Univ. Berlin (Germany)
Heinz-Johannes Buhr, Universitaetsklinikum Benjamin Franklin der Freie Univ. Berlin (Germany)
Kai-S. Lehmann, Universitaetsklinikum Benjamin Franklin der Freie Univ. Berlin (Germany)
Christoph-Thomas Germer, Universitaetsklinikum Benjamin Franklin der Freie Univ. Berlin (Germany)


Published in SPIE Proceedings Vol. 4161:
Optical Biopsy and Tissue Optics
Irving J. Bigio; Gerhard J. Mueller; Gerwin J. Puppels; Rudolf W. Steiner; Katarina Svanberg, Editor(s)

© SPIE. Terms of Use
Back to Top