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Proceedings Paper

Sensitivity analysis of near-infrared glucose absorption signals: toward noninvasive blood glucose sensing
Author(s): Vidi A. Saptari; Kamal Youcef-Toumi
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Paper Abstract

Noninvasive blood glucose monitoring is a long pursued goal in clinical diagnostic. Among several other optical methods, near infrared absorption spectroscopy is the most promising one for the noninvasive application to date. However, realization has not been achieved. A major obstacle is the low signal-to-noise ration pertinent to physiological blood glucose measurement using the near infrared absorption technique. Sensitivity analysis of aqueous glucose absorption signals was performed in the combination band region and in the first-overtone region. The analysis involved quantification of both glucose absorption signal and the corresponding spectral noise within a particular wavelength region. Glucose absorption band at 4430cm-1 (2257nm) in the combination band region was found to give an order of magnitude higher signal-to-noise ratio than the strongest band in the first-overtone region. A Fourier- filtering algorithm was applied to the raw absorbance data to remove some of the unwanted spectral variations. With simple peak-to-peak analysis to the Fourier-filtered absorbance data, repeatability of less than ±0.5mmol/L was achieved. In addition, effects of temperature variations on the absorption spectra were studied. The effects of sample temperature were compensated with the application of the Fourier filter.

Paper Details

Date Published: 22 November 2000
PDF: 10 pages
Proc. SPIE 4163, Optical Techniques and Instrumentation for the Measurement of Blood Composition, Structure, and Dynamics, (22 November 2000); doi: 10.1117/12.407644
Show Author Affiliations
Vidi A. Saptari, Massachusetts Institute of Technology (United States)
Kamal Youcef-Toumi, Massachusetts Institute of Technology (United States)


Published in SPIE Proceedings Vol. 4163:
Optical Techniques and Instrumentation for the Measurement of Blood Composition, Structure, and Dynamics
Alexander V. Priezzhev; P. Ake Oberg, Editor(s)

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