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Proceedings Paper

Effect of discrete scatterers in CSF layer on optical path length in the brain
Author(s): Eiji Okada; David T. Delpy
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Paper Abstract

Adequate modeling of light propagation in the complex and heterogeneous tissue of the human head is very important for quantitative near infrared spectroscopy and optical imaging. The presence of a clear and non-scattering CSF layer around the brain has been previously shown to strongly affect light propagation in the head. However the CSF layer is not totally filled with a non-scattering fluid and quite a few fine arachnoid trabeculae are actually present in the layer. In this study light propagation in an adult head model with discrete scatterers distributed within the CSF layer has been predicted by Monte Carlo simulation in order to investigate the effect of scattering caused by the arachnoid trabecula in the CSF layer. Results show that the presence of the arachnoid trabeculae affect the total optical path length, a parameter which can be directly measured by time-resolved measurement. However, the partial optical path length in the brain tissue, which relates the sensitivity of the near infrared spectroscopy signal to absorption changes in the brain is strongly affected by the CSF layer even in the presence of the arachnoid trabeculae. The increased partial optical path length results from an increased lateral spreading of the NIR light within the gray matter of the cortex.

Paper Details

Date Published: 22 November 2000
PDF: 8 pages
Proc. SPIE 4160, Photon Migration, Diffuse Spectroscopy, and Optical Coherence Tomography: Imaging and Functional Assessment, (22 November 2000); doi: 10.1117/12.407621
Show Author Affiliations
Eiji Okada, Keio Univ. (Japan)
David T. Delpy, Univ. College London (United Kingdom)


Published in SPIE Proceedings Vol. 4160:
Photon Migration, Diffuse Spectroscopy, and Optical Coherence Tomography: Imaging and Functional Assessment
Stefan Andersson-Engels; James G. Fujimoto, Editor(s)

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