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Proceedings Paper

Progress in photodynamic method of tumor diagnosis and treatment
Author(s): Alfreda Graczyk; Miroslaw Kwasny; Zygmunt Mierczyk
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Paper Abstract

Development of photodymanic method for tumors diagnosis and therapy (PDT) was observed in the early 70's. The third stage of clinical investigations in the USA, Canada, Japan, and in European countries has begun since 1988. Tumors treatment consists in selective oxidation of biological material of a tumor tissue by a singlet oxygen or radical forms. Such forms are generated due to molecular oxygen, soluted in cells, exogeneously introduced photosensitiser which is better accumulated in the diseased tissues than in healthy ones and delivered light of adequate power and wavelength. Such therapeutic method allows selective destruction of tumor tissues, simultaneously protecting the healthy ones. Tumors diagnostics relies on localisation of photosensitisers, absorbed in tumor tissues, by means of fluorometric methods. Investigations with PDT method are carried out in several direction, i.e., synthesis and application of new photosensitisers, design of new light sources, radiation dosimetry in tissues, mechanisms of photochemical reaction, and clinical applications of PDT method. PDT method for tumors treatment compared to traditional ones (surgery, irradiation, chemotherapy) is much more selective but is constrained by many factors limiting its intensive development and clinical applications. In Poland the PDT method is applied in several clinics for treatment of skin tumors, lungs, gynaecological sphere, and urinary bladder. The paper presents current status and perspectives of development of this method. Technology for production of our own photosensitisers (aminoacid complexes and protoporphyrines) is implemented and adequate diagnostic and therapeutic systems have been constructed. Investigations required for specimens admission to clinical application were carried out.

Paper Details

Date Published: 2 November 2000
PDF: 9 pages
Proc. SPIE 4238, Laser Technology VI: Applications, (2 November 2000); doi: 10.1117/12.405954
Show Author Affiliations
Alfreda Graczyk, Military Univ. of Technology (Poland)
Miroslaw Kwasny, Military Univ. of Technology (Poland)
Zygmunt Mierczyk, Military Univ. of Technology (Poland)

Published in SPIE Proceedings Vol. 4238:
Laser Technology VI: Applications
Wieslaw L. Wolinski; Zdzislaw Jankiewicz, Editor(s)

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