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Proceedings Paper

Novel cancer diagnostic method: FCLA-assisted sonodynamic diagnosis
Author(s): Yonghong He; Da Xing; Yong Yao; Yonghong Tang; Shici Tan
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Paper Abstract

In this paper, we propose, for the first time, the concept of Sono-Dynamic Diagnosis (SDD). The novel method named FCLA Assisted Sono-Dynamic Diagnosis is designed as follows: HpD is used to localize the cancer tissue, and is sonosensitized by the ultrasound field to produce singlet oxygen. Then, another reagent, FCLA (Fluoresceinyl Cypridina Luminescent Analog), reacts with O2 to efficiently transform the chemical energy of O2 to photons, thus a strong chemiluminescence is emitted. One can then detect this emission with a high sensitive CCD imaging system to localize the tumor. Based on the principle of FCLA assisted SDD, we obtained a clear diagnostic image of a transplanted tumor in a nude mouse in the experiments. It is shown that the emission from the tumor region is much stronger than that from other regions. The outline of the tumor is quite clear. This method could have potential applications in clinics for early-stage tumor diagnosis.

Paper Details

Date Published: 3 November 2000
PDF: 8 pages
Proc. SPIE 4162, Controlling Tissue Optical Properties: Applications in Clinical Study, (3 November 2000); doi: 10.1117/12.405928
Show Author Affiliations
Yonghong He, South China Normal Univ. (China)
Da Xing, South China Normal Univ. (China)
Yong Yao, South China Normal Univ. (China)
Yonghong Tang, South China Normal Univ. (China)
Shici Tan, South China Normal Univ. (China)


Published in SPIE Proceedings Vol. 4162:
Controlling Tissue Optical Properties: Applications in Clinical Study
Valery V. Tuchin, Editor(s)

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