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Proceedings Paper

Development of a multispectral autoradiography using a coded aperture
Author(s): Daisuke Noto; Tohoru Takeda; Jin Wu; Thet Thet Lwin; Quanwen Yu; Tsutomu Zeniya; Tetsuya Yuasa; Yukio Hiranaka; Yuji Itai; Takao Akatsuka
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Paper Abstract

Autoradiography is a useful imaging technique to understand biological functions using tracers including radio isotopes (RI's). However, it is not easy to describe the distribution of different kinds of tracers simultaneously by conventional autoradiography using X-ray film or Imaging plate. Each tracer describes each corresponding biological function. Therefore, if we can simultaneously estimate distribution of different kinds of tracer materials, the multispectral autoradiography must be a quite powerful tool to better understand physiological mechanisms of organs. So we are developing a system using a solid state detector (SSD) with high energy- resolution. Here, we introduce an imaging technique with a coded aperture to get spatial and spectral information more efficiently. In this paper, the imaging principle is described, and its validity and fundamental property are discussed by both simulation and phantom experiments with RI's such as 201Tl, 99mTc, 67Ga, and 123I.

Paper Details

Date Published: 2 November 2000
PDF: 11 pages
Proc. SPIE 4113, Algorithms and Systems for Optical Information Processing IV, (2 November 2000); doi: 10.1117/12.405842
Show Author Affiliations
Daisuke Noto, Yamagata Univ. (Japan)
Tohoru Takeda, Univ. of Tsukuba (Japan)
Jin Wu, Univ. of Tsukuba (Japan)
Thet Thet Lwin, Univ. of Tsukuba (Japan)
Quanwen Yu, Yamagata Univ. (Japan)
Tsutomu Zeniya, Yamagata Univ. (Japan)
Tetsuya Yuasa, Yamagata Univ. (Japan)
Yukio Hiranaka, Yamagata Univ. (Japan)
Yuji Itai, Univ. of Tsukuba (Japan)
Takao Akatsuka, Yamagata Univ. (Japan)

Published in SPIE Proceedings Vol. 4113:
Algorithms and Systems for Optical Information Processing IV
Bahram Javidi; Demetri Psaltis, Editor(s)

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