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Proceedings Paper

Micromachined muscle cell analysis chip
Author(s): Weijie Wang; Paul C. H. Li; M. Parameswaran
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Paper Abstract

We report the fabrication of a microfluidic biochip integrated with an acoustic wave sensor that can be used to characterize the contraction of single cardiac (heart) muscle cells. The work will lead to rapid analysis of single muscle cells in response to various drugs by determining changes in mass and viscoelastic properties during cell contraction and relaxation. The microfabricated device is a combination of a top cover plate which is a glass substrate containing etched channels and a bottom plate which is an AT-cut quartz crystal with excitation electrodes. The glass plate is micromachined with a network of channels and chambers, which is intended for delivery of fluids, selection and retention of single muscle cells. The bottom plate (quartz crystal) comprises all the patterned electrodes for acoustic wave launching and detection. The quartz plate is operated in the thickness-shear acoustic wave mode.

Paper Details

Date Published: 20 October 2000
PDF: 9 pages
Proc. SPIE 4230, Micromachining and Microfabrication, (20 October 2000); doi: 10.1117/12.404891
Show Author Affiliations
Weijie Wang, Simon Fraser Univ. (Canada)
Paul C. H. Li, Simon Fraser Univ. (Canada)
M. Parameswaran, Simon Fraser Univ. (Canada)

Published in SPIE Proceedings Vol. 4230:
Micromachining and Microfabrication
Kevin H. Chau; M. Parameswaran; Francis E.H. Tay, Editor(s)

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