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Proceedings Paper

Stochastic modeling for magnetic resonance quantification of myocardial blood flow
Author(s): Ravi Teja Seethamraju; Olaf Muehling; Prasad M. Panse; Norbert M. Wilke; Michael Jerosch-Herold
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Paper Abstract

Quantification of myocardial blood flow is useful for determining the functional severity of coronary artery lesions. With advances in MR imaging it has become possible to assess myocardial perfusion and blood flow in a non-invasive manner by rapid serial imaging following injection of contrast agent. To date most approaches reported in the literature relied mostly on deriving relative indices of myocardial perfusion directly from the measured signal intensity curves. The central volume principle on the other hand states that it is possible to derive absolute myocardial blood flow from the tissue impulse response. Because of the sensitivity involved in deconvolution due to noise in measured data, conventional methods are sub-optimal, hence, we propose to use stochastic time series modeling techniques like ARMA to obtain a robust impulse response estimate. It is shown that these methods when applied for the optical estimation of the transfer function give accurate estimates of myocardial blood flow. The most significant advantage of this approach, compared with compartmental tracer kinetic models, is the use of a minimum set of prior assumptions on data. The bottleneck in assessing myocardial blood flow, does not lie in the MRI acquisition, but rather in the effort or time for post processing. It is anticipated that the very limited requirements for user input and interaction will be of significant advantage for the clinical application of these methods. The proposed methods are validated by comparison with mean blood flow measurements obtained from radio-isotope labeled microspheres.

Paper Details

Date Published: 4 October 2000
PDF: 8 pages
Proc. SPIE 4121, Mathematical Modeling, Estimation, and Imaging, (4 October 2000); doi: 10.1117/12.402434
Show Author Affiliations
Ravi Teja Seethamraju, Univ. of Minnesota/Twin Cities (United States)
Olaf Muehling, Univ. of Minnesota/Twin Cities (United States)
Prasad M. Panse, Univ. of Minnesota/Twin Cities (United States)
Norbert M. Wilke, Univ. of Minnesota/Twin Cities (United States)
Michael Jerosch-Herold, Univ. of Minnesota/Twin Cities (United States)


Published in SPIE Proceedings Vol. 4121:
Mathematical Modeling, Estimation, and Imaging
David C. Wilson; Hemant D. Tagare; Fred L. Bookstein; Francoise J. Preteux; Edward R. Dougherty, Editor(s)

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