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Proceedings Paper

Clinical experiences with fluorescence guided resection of malignant glioma
Author(s): Walter Stummer; Susanne Stocker; Herbert G. Stepp; Karl Bise; Hanns-Juergen Reulen; Reinhold Baumgartner
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Paper Abstract

Survival after surgery and radiotherapy of malignant glioma is closely linked to the completeness of tumor removal. Therefore methods are needed that permit intra-operative identification of tumor border lines. For tumor staining 5-ALA induced PPIX is used. The influence of fluorescence guided resection on the survival is analyzed. 66 patients received 20 mg/kg bodyweight 5-ALA per os 3 hours before anaesthesia. Fluorescence was visualized using a modified operating microscope. Fluorescing tissue was removed as complete as possible. 72 hours after surgery MIII —images were taken and residual enhancements quantified. Patients survival was analysed using the Kaplan-Meier method in correlation with Karnofsky-status, age, histology of tumor. These 66 patients were compared to 89 patients operated on between 1990 — 1992. Complete resection ofmalignant and fluorescing tumor was obtained in 62 % of patients. Compared to the historical group ofpatients survival using 5-ALA was significantly prolonged.

Paper Details

Date Published: 28 June 2000
PDF: 4 pages
Proc. SPIE 4166, Laser Florence '99: A Window on the Laser Medicine World, (28 June 2000); doi: 10.1117/12.389472
Show Author Affiliations
Walter Stummer, Klinikum Grosshadern/Ludwig-Maximilians-Univ. Muenchen (Germany)
Susanne Stocker, Klinikum Grosshadern/Ludwig-Maximilians-Univ. Muenchen (Germany)
Herbert G. Stepp, Klinikum Grosshadern/Ludwig-Maximilians-Univ. Muenchen (Germany)
Karl Bise, Klinikum Grosshadern/Ludwig-Maximilians-Univ. Muenchen (Germany)
Hanns-Juergen Reulen, Klinikum Grosshadern/Ludwig-Maximilians-Univ. Muenchen (Germany)
Reinhold Baumgartner, Klinikum Grosshadern/Ludwig-Maximilians-Univ. Muenchen (Germany)

Published in SPIE Proceedings Vol. 4166:
Laser Florence '99: A Window on the Laser Medicine World
Leonardo Longo; Alfons G. Hofstetter; Mihail-Lucian Pascu; Wilhelm R.A. Waidelich, Editor(s)

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