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Proceedings Paper

Basic principles of fluorescence detection with use of 5-ALA
Author(s): Reinhold Baumgartner; Herbert G. Stepp
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Paper Abstract

5-Aminolevulinic acid (5-ALA) has been proven to induce selective accumulation of flourescent Protoporphyrin IX (PPIX) in many types of malignant tissue. According to the target to treatment different routes of topical and systemical application of 5-ALA can be chosen. They include techniques like inhalation, installation and rinsing. For fluorescence detection a lamp based system have been developed in the laser-Forschungslabor in Munich together with Storz company. By skillful balancing of excitation filter centered around 400 nm and the observation filter with transmission above 450 nm images with high color contrast can be obtained. The universal application of the D-LIGHT could be demonstrated in different clinical disciplines like urology, neurosurgery, ENT clinic, gynecology and others.

Paper Details

Date Published: 28 June 2000
PDF: 3 pages
Proc. SPIE 4166, Laser Florence '99: A Window on the Laser Medicine World, (28 June 2000); doi: 10.1117/12.389470
Show Author Affiliations
Reinhold Baumgartner, Klinikum Grosshadern/Ludwig-Maximilians-Univ. Muenchen (Germany)
Herbert G. Stepp, Klinikum Grosshadern/Ludwig-Maximilians-Univ. Muenchen (Germany)

Published in SPIE Proceedings Vol. 4166:
Laser Florence '99: A Window on the Laser Medicine World
Leonardo Longo; Alfons G. Hofstetter; Mihail-Lucian Pascu; Wilhelm R.A. Waidelich, Editor(s)

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