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Proceedings Paper

Engineered matrices for bone regeneration
Author(s): Shelley R. Winn; Yunhua Hu; Amy Pugh; Leanna Brown; Jesse T. Nguyen; Jeffrey O. Hollinger
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Paper Abstract

Traditional therapies of autografts and allogeneic banked bone can promote reasonable clinical outcome to repair damaged bone. However, under certain conditions the success of these traditional approaches plummets, providing the incentive for researchers to develop clinical alternatives. The evolving field of tissue engineering in the musculoskeletal system attempts to mimic many of the components from the intact, healthy subject. Those components consist of a biologic scaffold, cells, extracellular matrix, and signaling molecules. The bone biomimetic, i.e., an engineered matrix, provides a porous structural architecture for the regeneration and ingrowth of osseous tissue at the site of injury. To further enhance the regenerative cascade, our strategy has involved porous biodegradable scaffolds containing and releasing signaling molecules and providing a suitable environment for cell attachment, growth and differentiation. In addition, the inclusion of genetically modified osteogenic precursor cells has brought the technology closer to developing a tissue-engineered equivalent. The presentation will describe various formulations and the methods utilized to evaluate the clinical utility of these biomimetics.

Paper Details

Date Published: 13 June 2000
PDF: 7 pages
Proc. SPIE 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical, (13 June 2000); doi: 10.1117/12.388078
Show Author Affiliations
Shelley R. Winn, Oregon Health Sciences Univ. (United States)
Yunhua Hu, Oregon Health Sciences Univ. (United States)
Amy Pugh, Oregon Health Sciences Univ. (United States)
Leanna Brown, Oregon Health Sciences Univ. (United States)
Jesse T. Nguyen, Oregon Health Sciences Univ. (United States)
Jeffrey O. Hollinger, Oregon Health Sciences Univ. (United States)


Published in SPIE Proceedings Vol. 3914:
Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical
Jeffrey O. Hollinger; Donald Dean Duncan; Jeffrey O. Hollinger; Donald Dean Duncan; Steven L. Jacques, Editor(s)

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