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Proceedings Paper

Formation of nitric oxide under action of UV and visible light on S-nitrosocompounds
Author(s): Ivan I. Stepuro; Raisa I. Adamchuk; Slavomir S. Anufrik; Vitali I. Stepuro; Sergei A. Maskevich
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Paper Abstract

It has been shown that NO is released under the exposure of the aqueous solutions of S-nitrosocompounds as well as blood plasma proteins and whole blood of healthy donors to UV and visible light. The NO release from degrading S- nitrosocompounds was monitored both spectrophotometrically (by nitrosohemoglobin formation) and using the quenching of pyrene fluorescence by nitric oxide. In addition to NO, thyil radicals which dismutate to disulfides, were formed under anaerobic conditions. In the presence of oxygen, peroxide compounds, cysteine acid derivatives and S-nitrocompounds are formed apart from disulfides, and NO is mainly converted to NO2-. It is suggested that NO releasing under the actin of UV and visible light from physiological depots induces vascular relaxation, which enhances the blood flow.

Paper Details

Date Published: 13 June 2000
PDF: 6 pages
Proc. SPIE 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical, (13 June 2000); doi: 10.1117/12.388077
Show Author Affiliations
Ivan I. Stepuro, Institute of Biochemistry (Belarus)
Raisa I. Adamchuk, Institute of Biochemistry (Belarus)
Slavomir S. Anufrik, State Univ. of Grodno (Belarus)
Vitali I. Stepuro, State Univ. of Grodno (Belarus)
Sergei A. Maskevich, State Univ. of Grodno (Belarus)

Published in SPIE Proceedings Vol. 3914:
Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical
Jeffrey O. Hollinger; Donald Dean Duncan; Jeffrey O. Hollinger; Donald Dean Duncan; Steven L. Jacques, Editor(s)

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