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Proceedings Paper

Corneal and skin laser exposures from 1540-nm laser pulses
Author(s): Thomas E. Johnson; Michael A. Mitchell; Pedro J. Rico; David J. Fletcher; Thomas E. Eurell; William P. Roach
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Paper Abstract

Mechanisms of tissue damage are investigated for skin and cornea exposures from 1540 nm ('eye safe') laser single pulses of 0.8 milli-seconds. New skin model data point out the advantages of using the Yucatan mini-pig versus the Yorkshire pig for in-vivo skin laser exposures. Major advantages found include similarities in thickness and melanin content when compared with human skin. Histology from Yucatan mini-pig skin exposures and the calculation of an initial ED50 threshold indicate that the main photon tissue interaction may not be solely due to water absorption. In-vitro corneal equivalents compared well with in-vivo rabbit cornea exposure under similar laser conditions. In-vivo and in-vitro histology show that initial energy deposition leading to damage occurs intrastromally, while epithelial cells show no direct injury due to laser light absorption.

Paper Details

Date Published: 13 June 2000
PDF: 8 pages
Proc. SPIE 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical, (13 June 2000); doi: 10.1117/12.388049
Show Author Affiliations
Thomas E. Johnson, Uniformed Services Univ. of the Health Sciences (United States)
Michael A. Mitchell, Uniformed Services Univ. of the Health Sciences (United States)
Pedro J. Rico, Uniformed Services Univ. of the Health Sciences (United States)
David J. Fletcher, Uniformed Services Univ. of the Health Sciences (United States)
Thomas E. Eurell, Univ. of Illinois/Urbana-Champaign (United States)
William P. Roach, Uniformed Services Univ. of the Health Sciences (United States)


Published in SPIE Proceedings Vol. 3914:
Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical
Jeffrey O. Hollinger; Donald Dean Duncan; Jeffrey O. Hollinger; Donald Dean Duncan; Steven L. Jacques, Editor(s)

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