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Proceedings Paper

Further characterization of photothermal breakdown products of uric acid stones following holmium:YAG laser lithotripsy
Author(s): Randolph D. Glickman; Susan T. Weintraub; Neeru Kumar; Nicole S. Corbin; Omid Lesani; Joel M. H. Teichman
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Paper Abstract

Previously we found that Ho:YAG laser (2120 nm) lithotripsy of uric acid stones produced cyanide, a known thermal breakdown product of uric acid. We now report that alloxan, another thermal breakdown product, is also likely produced. Uric acid stones (approximately 98% pure) of human origin were placed in distilled water and subjected to one of the following experimental treatments: unexposed control, exposed to Ho:YAG laser, Nd:YAG laser, or mechanically crushed. Samples were then processed for HPLC analysis with UV detection. Peaks were identified by comparison to authentic standards. All samples contained uric acid, with retention time (RT) about 6 min. All of the laser-exposed samples contained a peak that eluted at 2.5 min, identical to the RT of authentic alloxan. Ho:YAG laser irradiation, however, produced a larger presumed alloxan peak than did the Nd:YAG laser. The peak at 2.5 min, as well as unidentified later-eluting peaks, were present in the laser-exposed, but not the unexposed or mechanically crushed, samples. These results confirm the thermal nature of lithotripsy performed with long-pulse IR lasers.

Paper Details

Date Published: 13 June 2000
PDF: 9 pages
Proc. SPIE 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical, (13 June 2000); doi: 10.1117/12.388040
Show Author Affiliations
Randolph D. Glickman, Univ. of Texas Health Science Ctr. at San Antonio (United States)
Susan T. Weintraub, Univ. of Texas Health Science Ctr. at San Antonio (United States)
Neeru Kumar, Univ. of Texas Health Science Ctr. at San Antonio (United States)
Nicole S. Corbin, Univ. of Texas Health Science Ctr. at San Antonio (United States)
Omid Lesani, Univ. of Texas Health Science Ctr. at San Antonio (United States)
Joel M. H. Teichman, Univ. of Texas Health Science Ctr. at San Antonio (United States)


Published in SPIE Proceedings Vol. 3914:
Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical
Jeffrey O. Hollinger; Donald Dean Duncan; Jeffrey O. Hollinger; Donald Dean Duncan; Steven L. Jacques, Editor(s)

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