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Proceedings Paper

Tracking interval changes of pulmonary nodules using a sequence of three-dimensional thoracic images
Author(s): Yoshiki Kawata; Noboru Niki; Hironobu Omatsu; Masahiko Kusumoto; Ryutaro Kakinuma; Kiyoshi Mori; Hiroyuki Nishiyama; Kenji Eguchi; Masahiro Kaneko; Noriyuki Moriyama
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Paper Abstract

We are developing a computerized approach to characterize pulmonary nodules through quantitative analysis between sequential 3-D thoracic images. In this approach the registration procedure of sequential 3-D pulmonary images consisted of two transformation steps: the rigid transformation step between two sequential 3-D thoracic CT images and the affine transformation step between two sequential region-of-interest (ROI) images including the pulmonary nodule. In both transformation step, the normalized mutual information was used as a voxel-based similarity measure. After the registration procedure, the 3-D pulmonary nodule image was segmented from the ROI image by a deformable surface method. The curvatures of each voxel in the nodule were computed directly from the gray-level 3-D image. Through curvatures a local description of the lesion was obtained by using shape index, curvedness, and CT value. Based on this local description of the nodule, the evolution of geometrical parameters was tracked through the time interval. Additionally, to characterize globally the evolution of the local description, the shape and the curvedness spectra were introduced. The interval changes of the lesion were traced in the feature spaces. The application results of our method to the sequence of 3-D thoracic images demonstrated that the interval changes of pulmonary nodules could be made visible.

Paper Details

Date Published: 6 June 2000
PDF: 11 pages
Proc. SPIE 3979, Medical Imaging 2000: Image Processing, (6 June 2000); doi: 10.1117/12.387723
Show Author Affiliations
Yoshiki Kawata, Univ. of Tokushima (Japan)
Noboru Niki, Univ. of Tokushima (Japan)
Hironobu Omatsu, National Cancer Ctr. Hospital East (Japan)
Masahiko Kusumoto, National Cancer Ctr. Hospital (Japan)
Ryutaro Kakinuma, National Cancer Ctr. Hospital East (Japan)
Kiyoshi Mori, Togichi Cancer Ctr. (Japan)
Hiroyuki Nishiyama, Social Health Insurance Medical Ctr. (Japan)
Kenji Eguchi, National Shikoku Cancer Ctr. Hospital (Japan)
Masahiro Kaneko, National Cancer Ctr. Hospital (Japan)
Noriyuki Moriyama, National Cancer Ctr. Hospital (Japan)


Published in SPIE Proceedings Vol. 3979:
Medical Imaging 2000: Image Processing
Kenneth M. Hanson, Editor(s)

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