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Proceedings Paper

Validation of an optical flow algorithm to measure blood flow waveforms in arteries using dynamic digital x-ray images
Author(s): Kawal Rhode; Tryphon Lambrou; David John Hawkes; George Hamilton; Alexander M. Seifalian
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Paper Abstract

We have developed a weighted optical flow algorithm for the extraction of instantaneous blood velocity from dynamic digital x-ray images of blood vessels. We have carried out in- vitro validation of this technique. A pulsatile physiological blood flow circuit was constructed using sections of silicone tubing to simulate blood vessels with whole blood as the fluid. Instantaneous recording of flow from an electromagnetic flow meter (EMF) provided the gold standard measurement. Biplanar dynamic digital x-ray images of the blood vessel with injection of contrast medium were acquired at 25 fps using a PC frame capture card. Imaging of a Perspex calibration cube allowed 3D reconstruction of the vessel and determination of true dimensions. Blood flow waveforms were calculated off-line on a Sun workstation using the new algorithm. The correlation coefficient between instantaneous blood flow values obtained from the EMF and the x-ray method was r equals 0.871, n equals 1184, p less than 0.0001. The correlation coefficient for average blood flow was r equals 0.898, n equals 16, p less than 0.001. We have successfully demonstrated that our new algorithm can measure pulsatile blood flow in a vessel phantom. We aim to use this algorithm to measure blood flow clinically in patients undergoing vascular interventional procedures.

Paper Details

Date Published: 6 June 2000
PDF: 12 pages
Proc. SPIE 3979, Medical Imaging 2000: Image Processing, (6 June 2000); doi: 10.1117/12.387652
Show Author Affiliations
Kawal Rhode, Royal Free Hospital/Royal Free and Univ. College Medical School (United Kingdom)
Tryphon Lambrou, Guy's Hospital/Guy's, King's, and St. Thomas' School of Medicine (United Kingdom)
David John Hawkes, Guy's Hospital/Guy's, King's, and St. Thomas' School of Medicine (United Kingdom)
George Hamilton, Royal Free Hospital/Royal Free and Univ. College Medical School (United Kingdom)
Alexander M. Seifalian, Royal Free Hospital/Royal Free and Univ. College Medical School (United Kingdom)


Published in SPIE Proceedings Vol. 3979:
Medical Imaging 2000: Image Processing
Kenneth M. Hanson, Editor(s)

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