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Proceedings Paper

New clinical instrument for the early detection of cataract using dynamic light scattering and corneal topography
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Paper Abstract

A growing cataract can be detected at the molecular level using the technique of dynamic light scattering (DLS). However, the success of this method in clinical use depends upon the precise control of the scattering volume inside a patient's eye and especially during patient's repeat visits. This is important because the scattering volume (cross-over region between the scattered light and incident light) inside the eye in a high-quality DLS set-up is very small (few microns in dimension). This precise control holds the key for success in the longitudinal studies of cataract and during anti-cataract drug screening. We have circumvented these problems by fabricating a new DLS fiber optic probe with a working distance of 40 mm and by mounting it inside a cone of a corneal analyzer. This analyzer is frequently used in mapping the corneal topography during PRK (photorefractive keratectomy) and LASIK (laser in situ keratomileusis) procedures in shaping of the cornea to correct myopia. This new instrument and some preliminary clinical tests on one of us (RRA) showing the data reproducibility are described.

Paper Details

Date Published: 7 June 2000
PDF: 12 pages
Proc. SPIE 3908, Ophthalmic Technologies X, (7 June 2000); doi: 10.1117/12.387509
Show Author Affiliations
Rafat R. Ansari, NASA Glenn Research Ctr. (United States)
Manuel B. Datiles, National Institutes of Health (United States)
James F. King, NASA Glenn Research Ctr. (United States)


Published in SPIE Proceedings Vol. 3908:
Ophthalmic Technologies X
Pascal O. Rol; Karen Margaret Joos; Fabrice Manns, Editor(s)

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