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Proceedings Paper

Computerized video-enhanced high temporal resolution of erythrocytes sedimentation rate (ESR-graphy) reveals complex dynamic and self-organizing properties of whole blood
Author(s): Vladimir L. Voeikov; Sergey E. Kondakov; Ekaterina Buravleva; Isaak Kaganovsky; Mikhail Reznikov
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Paper Abstract

An automatic device for high-temporal resolution of the process of red blood sedimentation was designed. The position of the boundary between red blood and plasma may be registered each 30 sec in several pipettes simultaneously with +/- 10 mkm precision. Fractional rates of the boundary movement are deduced with high accuracy. Data are processed by a PC and presented as velocity-time curves (ESR-grams) and the curves describing time evolution of the boundary position. Several unexpected phenomena in the process of red blood sedimentation have been revealed. Upward fast movements of the boundary up to 1 mm were noted. In patients' blood sets of 5 - 10 milliHz oscillations of sedimentation rate were usually developing at early stages of blood sedimentation. In non-diluted healthy donors' blood high amplitude periodic oscillations were either absent, or were emerging only after blood resided in pipettes for several hours. When blood was diluted to a certain degree with physiological saline or with own plasma long-term low frequency (1 - 3 milliHz) rate oscillations regularly appeared. Non-trivial dependence of patterns of ESR-grams on diluting of blood with own plasma or saline was observed. Thus, non-linear dynamic behavior of living blood has been revealed due to application of the principles of the system of technical vision for the detailed analysis of red blood sedimentation kinetics.

Paper Details

Date Published: 31 May 2000
PDF: 12 pages
Proc. SPIE 3923, Optical Diagnostics of Biological Fluids V, (31 May 2000); doi: 10.1117/12.387143
Show Author Affiliations
Vladimir L. Voeikov, M.V. Lomonosov Moscow State Univ. (Russia)
Sergey E. Kondakov, M.V. Lomonosov Moscow State Univ. (Russia)
Ekaterina Buravleva, M.V. Lomonosov Moscow State Univ. (Russia)
Isaak Kaganovsky, JSC Experimental Research Institute of Metal Cutters (Russia)
Mikhail Reznikov, JSC Experimental Research Institute of Metal Cutters (Russia)


Published in SPIE Proceedings Vol. 3923:
Optical Diagnostics of Biological Fluids V
Alexander V. Priezzhev; Toshimitsu Asakura, Editor(s)

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