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Proceedings Paper

Optical biopsy: in-vivo diagnosis of breast cancer using elastic scatter spectroscopy
Author(s): David Christopher O. Pickard; Gavin M. Briggs; Christobel Saunders; Sunil Lakhani; Paul M. Ripley; Irving J. Bigio; Stephen G. Bown
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Paper Abstract

Elastic scattering or diffuse reflectance spectroscopy offers the possibility of distinguishing between cancerous and non- cancerous tissue in the breast with a relatively simple optical measurement. The measurement of the relative reflection of light has previously been shown to be sensitive to both the size and distribution of intra and inter-cellular structures as well as absorption from chromophores, which are present in the tissue. Coupling a white light source and spectrometer to optic fibers makes it possible to construct probes that can be inserted percutaneously or used intra- operatively to take in-vivo spectra from breast tissue or ex- vivo spectra from excised sentinel nodes. This 'optical biopsy' is correlated with a conventional histopathological specimen obtained at the same point. Spectra are reported from a large number of patients with benign and malignant lesions. Some of the differences that appear in these spectra are outlined and the uses and limitations of this technique for in-vivo diagnosis are discussed. It is shown that to a relatively high degree of sensitivity and specificity it is possible to distinguish between malignant tumors, benign lesions and normal tissue.

Paper Details

Date Published: 17 May 2000
PDF: 8 pages
Proc. SPIE 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X, (17 May 2000); doi: 10.1117/12.386304
Show Author Affiliations
David Christopher O. Pickard, Univ. College London Medical School (United Kingdom)
Gavin M. Briggs, Univ. College London Medical School (United Kingdom)
Christobel Saunders, Univ. College London Medical School (United Kingdom)
Sunil Lakhani, Univ. College London Medical School (United Kingdom)
Paul M. Ripley, Los Alamos National Lab. (United States)
Irving J. Bigio, Los Alamos National Lab. (United States)
Stephen G. Bown, Univ. College London Medical School (United Kingdom)


Published in SPIE Proceedings Vol. 3907:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X
R. Rox Anderson; Kenton W. Gregory; Eugene A. Trowers; David S. Robinson; Kenneth Eugene Bartels; Lou Reinisch; Reza S. Malek; C. Gaelyn Garrett; Lloyd P. Tate; Hans-Dieter Reidenbach; Timothy A. Woodward; Kenneth Eugene Bartels; Lawrence S. Bass; George M. Peavy; C. Gaelyn Garrett; Kenton W. Gregory; Nikiforos Kollias; Harvey Lui; Reza S. Malek; George M. Peavy; Hans-Dieter Reidenbach; Lou Reinisch; David S. Robinson; Lloyd P. Tate; Eugene A. Trowers; Timothy A. Woodward, Editor(s)

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